Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Malignant Mesothelioma
E. Sementino, Y. Kadariya, M. Cheung, C. W. Menges, Y. Tan, A.-M. Kukuyan, U. Shrestha, S. Karchugina, K. Q. Cai, S. Peri, J. S. Duncan, J. Chernoff, J. R. Testa
This study shows that inactivating Pak2 reduces tumor development in Nf2-deficient mice, suggesting PAK inhibition could be a therapeutic strategy for NF2-deficient cancers.
bioRxiv · Jun 30, 2020 · PreprintCancer Biology