Author

S. Karchugina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Chernoff· 2 shared A.-M. Kukuyan· 1 shared B. Faezov· 1 shared B. J. Groendyke· 1 shared C. W. Menges· 1 shared E. S. Fischer· 1 shared E. Sementino· 1 shared G. Abalakov· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

J. Chernoff

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2 papers

Recent·Most cited

Development and utility of a PAK1-selective degrader

H.-Y. Chow, S. Karchugina, B. J. Groendyke, S. Toenjes, J. Hatcher, K. A. Donovan, E. S. Fischer, G. Abalakov, B. Faezov, R. L. Dunbrack, N. S. Gray, J. Chernoff

This study develops a PAK1-selective degrader, BJG-05-039, which shows enhanced anti-proliferative effects compared to the parent inhibitor NVS-PAK1-1 in PAK1-dependent cell lines.

bioRxiv · May 12, 2022Cancer Biology

Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Malignant Mesothelioma

E. Sementino, Y. Kadariya, M. Cheung, C. W. Menges, Y. Tan, A.-M. Kukuyan, U. Shrestha, S. Karchugina, K. Q. Cai, S. Peri, J. S. Duncan, J. Chernoff, J. R. Testa

This study shows that inactivating Pak2 reduces tumor development in Nf2-deficient mice, suggesting PAK inhibition could be a therapeutic strategy for NF2-deficient cancers.

bioRxiv · Jun 30, 2020 · PreprintCancer Biology