Author

J. R. Testa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

A. M. Bowcock· 1 shared A. Polo· 1 shared A.-M. Kukuyan· 1 shared C. W. Menges· 1 shared D. Hinds· 1 shared D. McCracken· 1 shared E. J. Kennedy· 1 shared E. Sementino· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. M. Bowcock

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Author profile →

2 papers

Recent·Most cited

Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Malignant Mesothelioma

E. Sementino, Y. Kadariya, M. Cheung, C. W. Menges, Y. Tan, A.-M. Kukuyan, U. Shrestha, S. Karchugina, K. Q. Cai, S. Peri, J. S. Duncan, J. Chernoff, J. R. Testa

This study shows that inactivating Pak2 reduces tumor development in Nf2-deficient mice, suggesting PAK inhibition could be a therapeutic strategy for NF2-deficient cancers.

bioRxiv · Jun 30, 2020 · PreprintCancer Biology

Kinetics characterization of ASXL1/2-mediated allosteric regulation of BAP1 deubiquitinase

H. Peng, J. Cassel, D. McCracken, J. W. Prokop, P. R. Collop, A. Polo, S. Joshi, J. P. Mandell, K. Ayyanathan, D. Hinds, S. B. Malkowicz, J. W. Harbour, A. M. Bowcock, J. Salvino, E. J. Kennedy, , F. J. Rauscher

This study characterizes the kinetics and stoichiometry of BAP1 and ASXL2 interactions, revealing their structural and functional properties in deubiquitinase activity.

bioRxiv · Feb 24, 2020Cancer Biology