Schwann cells modulate nociception in neurofibromatosis 1
Namrata G.R. Raut, Laura A. Maile, Leila M. Oswalt, Irati Mitxelena, Aaditya Adlakha, Kourtney L. Sprague, Ashley R. Rupert, Lane Bokros, Megan C. Hofmann, Jennifer Patritti Cram, Tilat A. Rizvi, Luis F. Queme, Kwangmin Choi, Nancy Ratner, Michael P. Jankowski
The paper shows that Schwann cell Nf1 loss causes mechanical pain via GDNF release, which affects adjacent neurons, suggesting cell-specific treatment strategies for NF1-related pain.
JCI Insight · Jan 22, 2024Peer-reviewedNeuroscience