Selective Pyroptosis in NF1-Deficient Cells through PKCδ Agonism
Liang Hu, Yuting Tang, Yuan Lin…·Nancy Ratner
This study identifies PKCδ agonism as a method to selectively induce pyroptosis in NF1-deficient cells by targeting KRAS-GDP interactions.
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Cincinnati Children's Hospital Medical CenterORCID 0000-0002-0881-9518Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Liang Hu, Yuting Tang, Yuan Lin…·Nancy Ratner
This study identifies PKCδ agonism as a method to selectively induce pyroptosis in NF1-deficient cells by targeting KRAS-GDP interactions.
Kassidy E Grover, Zoe Cappel, Avery M. Volz…·J. Elliott Robinson
This study shows that genetic activation of ERK2 in mice models key neurodevelopmental features of Rasopathy syndromes, including cognitive impairments and facial dysmorphology.
Namrata G.R. Raut, Laura A. Maile, Leila M. Oswalt…·Michael P. Jankowski
The paper shows that Schwann cell Nf1 loss causes mechanical pain via GDNF release, which affects adjacent neurons, suggesting cell-specific treatment strategies for NF1-related pain.
Jennifer Patritti Cram, Jianqiang Wu, Shinji Kuninaka…·Nancy Ratner
This study identifies P2RY14 as a regulator of cAMP signaling in Schwann cell precursors, showing its role in self-renewal and neurofibroma initiation in NF1 mutant cells.