Nancy Ratner

This study identifies PKCδ agonism as a method to selectively induce pyroptosis in NF1-deficient cells by targeting KRAS-GDP interactions.

This study shows that genetic activation of ERK2 in mice models key neurodevelopmental features of Rasopathy syndromes, including cognitive impairments and facial dysmorphology.

This study identifies 23 compounds that selectively kill NF1-deficient Schwann cells and shows their efficacy in vivo, with synergy when combined with Selumetinib.

This study identifies RalB as a novel binding partner for active Merlin and shows its role in regulating exocytosis through the RalA/B pathway, suggesting therapeutic potential for NF2-related schwannoma.

The paper shows that Schwann cell Nf1 loss causes mechanical pain via GDNF release, which affects adjacent neurons, suggesting cell-specific treatment strategies for NF1-related pain.

This paper analyzes genomic alterations in MPNST cell lines to challenge their current diagnosis, finding significant differences between NF1-related and sporadic lines.

This study identifies P2RY14 as a regulator of cAMP signaling in Schwann cell precursors, showing its role in self-renewal and neurofibroma initiation in NF1 mutant cells.

This study shows that Cdc42 in Sertoli cells is essential for adult spermatogenesis, as its deletion leads to loss of spermatogenic cells and infertility.

This paper shows that Nf1 deletion in oligodendrocytes causes brain structural and functional disruptions in mice, which are rescued by NOS inhibition.