Abdul A. Waheed

This study shows that NNRTI-induced premature protease activation reduces HIV-1 virion glycoprotein incorporation and infectivity by disrupting Gag lattice and membrane properties.

This study uses single-molecule imaging to show that maturation inhibitors alter Gag conformational dynamics and spatial heterogeneity in immature HIV-1 virions.

The paper introduces a mechanism-aware platform to determine functional viral enzyme thresholds, revealing differences in stoichiometric requirements and enabling antiviral hypersensitivity detection.

This study identifies PSGL-1's decameric repeats as critical for excluding HIV Env from virions through structural folding that spatially hinders Env incorporation.