Directed Evolution of Adenine Base Editors with Increased Activity and Therapeutic Application
Nicole M. Gaudelli, Dieter K. Lam, Holly A. Rees, Noris M. Solá-Esteves, Luis Alberto Barrera, David A. Born, Aaron Edwards, Jason M. Gehrke, Seung‐Joo Lee, Alexander Liquori, Ryan C. Murray, Michael S. Packer, Conrad Rinaldi, Ian M. Slaymaker, Jonathan S. Yen, , Giuseppe Ciaramella
This paper evolves adenine base editors (ABE8s) to improve editing efficiency and demonstrates their therapeutic application in human cells.
Nature Biotechnology · Apr 13, 2020Peer-reviewedGenomics