Author

Jason M. Gehrke

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Holly A. ReesiD· 2 shared J. Keith JoungiD· 2 shared Kendell ClementiD· 2 shared Luca PinelloiD· 2 shared Aaron Edwards· 1 shared Alexander Liquori· 1 shared Conrad Rinaldi· 1 shared Daniel E. BaueriD· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

Holly A. ReesORCID

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3 papers

Recent·Most cited

GenomicsNature BiotechnologyPeer-reviewedApr 13, 2020

Directed Evolution of Adenine Base Editors with Increased Activity and Therapeutic Application

Nicole M. Gaudelli, Dieter K. Lam, Holly A. Rees…·Giuseppe Ciaramella

This paper evolves adenine base editors (ABE8s) to improve editing efficiency and demonstrates their therapeutic application in human cells.

530 citationstop 1%

humanCRISPR screen

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BioinformaticsNature BiotechnologyPeer-reviewedFeb 26, 2019

Analysis and comparison of genome editing using CRISPResso2

Kendell Clement, Holly A. Rees, Matthew C. Canver…·Luca Pinello

CRISPResso2 is a software tool for analyzing genome editing data, providing allele-specific quantification and scalable alignment to assess editing efficiency and safety.

1,676 citationstop 1%

whole-genome sequencingexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintMar 1, 2018

High-precision CRISPR-Cas9 base editors with minimized bystander and off-target mutations

Jason M. Gehrke, Oliver Cervantes, Kendell Clement…·J. Keith Joung

This paper evaluates CRISPR-Cas9 base editors to minimize bystander and off-target mutations while improving precision in C-to-T DNA editing.

10 citations

experimental assay

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