B7-H1(PD-L1) confers chemoresistance through ERK and p38 MAPK pathway in tumor cells
Xiaosheng Wu, Yanli Li, Xin Liu, Siyu Cao, Susan M. Harrington, Chunhua Chen, Aaron S. Mansfiled, Roxana S. Dronca, Sean S. Park, Yiyi Yan, Eugene D. Kwon, Liewei Wang, Kun Ling, Haidong Dong
This study shows B7-H1(PD-L1) promotes chemoresistance in tumor cells via ERK pathway activation and reduces it via p38 MAPK pathway activation when B7-H1 is deficient.
bioRxiv · Apr 25, 2018 · PreprintCancer Biology