Haidong Dong

PD-L1 deletion or blockade regulate macrophage antigen presentation and checkpoint molecule surface levels

This study investigates how PD-L1 deletion or blockade affects macrophage antigen presentation and checkpoint molecule levels in different polarization states.

Intracranial Targeting of Cholesterol Processing Reveals a Therapeutic Vulnerability that Reprograms Glioblastoma and Promotes Antitumor Immunity

This study identifies cholesterol dependency as a therapeutic target in glioblastoma, showing that combined treatment with clemastine and bexarotene induces metabolic collapse and enhances antitumor immunity.

Integrative AI-Enabled Virtual Cell Modeling Reveals a Clinically Relevant Latent Effector State of Human CD8 T Cells Undetectable by Conventional Analyses

The paper uses AI to model CD8 T-cell responses during ICI therapy, identifying a latent effector state that conventional methods miss.

TBK1 and IKKϵ protect target cells from IFNγ-mediated T cell killing via an inflammatory apoptotic mechanism

This study shows that TBK1 and IKKε protect target cells from IFNγ-mediated T cell killing by suppressing inflammatory apoptosis and NFκB-driven inflammation.

ME1 Programs Latent Effector Capacity and Grounds a Mathematical Model of Reversible T Cell Exhaustion

This paper identifies ME1 as a key regulator of reversible T cell exhaustion and develops a mathematical model to predict ICI responsiveness based on latent effector capacity.

Latent Effector Capacity Governs Reversible T Cell Exhaustion: A Mathematical Model for Mechanistically Predictive AI in PD-1 Blockade

This paper develops a mathematical model to explain reversible T cell exhaustion and its response to PD-1 blockade, identifying latent epigenetic states that govern therapeutic outcomes.

Temporal single-cell profiling uncovers age-associated delays in immune resolution to respiratory viral infection

This study identifies age-associated delays in immune resolution to respiratory viral infection by analyzing single-cell RNA sequencing and flow cytometry data from young and aged mice.

Immunopipe: A comprehensive and flexible scRNA-seq and scTCR-seq data analysis pipeline

Immunopipe provides a flexible pipeline for integrated analysis of scRNA-seq and scTCR-seq data to enhance understanding of T-cell immunity and immunotherapy.

PD-1 prelimits both the cytotoxic and exhaustion potential in thymic CD8+ T cells and impacts the maintenance of peripheral tumor immunity

This study identifies PD-1's role in regulating effector potential and exhaustion in thymic CD8+ T cells, showing that PD-1 inhibition enhances expansion but leads to exhaustion in tumor tissues.

Single CAR-Dual target: Intracranial Delivery of Anti-PD-L1 CAR T Cells Effectively Eradicates Glioma and Immunosuppressive Cells in the Tumor Microenvironment.

This study develops a PD-L1-targeting CAR T cell therapy, MC9999, which effectively eradicates glioblastoma and immunosuppressive cells in the tumor microenvironment through intracranial delivery.

Advancing CAR T-Cell Therapy: Simultaneously Attack Tumor and Immunosuppressive Cells in the Tumor Microenvironment

This paper develops a PD-L1-targeting CAR T-cell therapy (MC9999) that effectively attacks both tumor and immunosuppressive cells in solid tumors.

TREM2 mediates MHCII-associated CD4+ T cell response against gliomas

The paper shows that higher TREM2 expression in gliomas correlates with poor prognosis, but TREM2 deficiency does not improve outcomes in pre-clinical models, as it impairs myeloid cell phagocytosis and MHCII-dependent CD4+ T cell responses.

B7-H1(PD-L1) confers chemoresistance through ERK and p38 MAPK pathway in tumor cells

This study shows B7-H1(PD-L1) promotes chemoresistance in tumor cells via ERK pathway activation and reduces it via p38 MAPK pathway activation when B7-H1 is deficient.

Prevailing homozygous deletion of interferon and defensin genes in human cancers

The paper identifies widespread homozygous deletions of interferon and defensin genes in human cancers, linked to poor patient survival and altered TNF/IFNγ gene expression.