Maladaptive Piezo1 Mechanotransduction Drives Smooth Muscle Aging in the Gut
Vikram Joshi, Corey Seavey, Kaitlyn R. Knutson, Abhilash Sawant, Yasmeen M. F. Hamed, Mario D’Ambrosio, Emma Laible, Vladimir Dokic, Jason P. Sinnwell, Yuanhang Liu, Franco F Jin, Colin Thomas, Gwyneth K. Garramone, Amelia Mazzone, Ferdinando Bonfiglio, , Arthur Beyder
This study identifies maladaptive Piezo1 mechanotransduction as a driver of smooth muscle aging in the gut, showing it impairs contractility and contributes to gastrointestinal dysfunction.
bioRxiv · Sep 7, 2026 · PreprintPhysiology