Progressive behavioral and cognitive decline in Drosophila harboring AD-associated APOE4 variants
Samaneh Biglari, Eshani Yeragi, David Bamisaye, Christian Gonzalez, Renata García, Alexandra Losoya, Abhimanyu Arekere, Ciara Payne, Matthew J. Moulton, Alex C. Keene
This study shows that Drosophila with APOE4 variants exhibit AD-like phenotypes under stress and metabolic challenges, supporting a multi-hit model of disease.
bioRxiv · Sep 12, 2026 · PreprintGenetics