Author

Christian Gonzalez

Amsterdam Neuroscience

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1 Assay:Ribo-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Peter A. SimsiD· 2 shared Abhimanyu Arekere· 1 shared Adam M. SonabendiD· 1 shared Alex C. KeeneiD· 1 shared Alexandra Losoya· 1 shared Andrea CalifanoiD· 1 shared Angeliki MelaiD· 1 shared Ciara Payne· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersSystems Biology

Peter A. SimsORCID

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3 papers

Recent·Most cited

Progressive behavioral and cognitive decline in Drosophila harboring AD-associated APOE4 variants

Samaneh Biglari, Eshani Yeragi, David Bamisaye, Christian Gonzalez, Renata García, Alexandra Losoya, Abhimanyu Arekere, Ciara Payne, Matthew J. Moulton, Alex C. Keene

This study shows that Drosophila with APOE4 variants exhibit AD-like phenotypes under stress and metabolic challenges, supporting a multi-hit model of disease.

bioRxiv · Sep 12, 2026 · PreprintGenetics

High-Throughput Translational Profiling with riboPLATE-seq

Jordan B. Metz, Nicholas J. Hornstein, Sohani Das Sharma, Jeremy Worley, Christian Gonzalez, Peter A. Sims

This study introduces riboPLATE-seq, a method for generating paired libraries of ribosome-associated and total mRNA, and demonstrates its use in detecting translational changes caused by kinase inhibitors.

Scientific Reports · Apr 5, 2022Peer-reviewedSystems Biology

Quantitative Assessment of Protein Activity in Orphan Tissues and Single Cells Using the metaVIPER Algorithm

Hongxu Ding, Eugene F. Douglass, Adam M. Sonabend, Angeliki Mela, Sayantan Bose, Christian Gonzalez, Peter Canoll, Peter A. Sims, Mariano J. Alvarez, Andrea Califano

The paper introduces metaVIPER, an algorithm to assess protein activity in orphan tissues and single cells by integrating multiple non-tissue-matched interactomes, improving reproducibility of protein-activity signatures.

Nature Communications · Apr 11, 2018Peer-reviewedSystems Biology