Matthew J. Moulton

This study shows that Drosophila with APOE4 variants exhibit AD-like phenotypes under stress and metabolic challenges, supporting a multi-hit model of disease.

The paper identifies an AD protective allele of CLU that enhances neuronal excitability via lipid-droplet-mediated neuron-glia communication.

This study identifies cell-specific roles of AD risk genes in ROS-induced glial lipid droplet formation and shows how their loss affects Aβ42 toxicity and plaque formation.

The paper identifies O-GlcNAcylation as a regulatory mechanism for Dpp signaling in Drosophila, showing that Sxc inhibits Saxophone receptor activity to control BMP signaling and embryonic development.