Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability
Sophie Dürauer, Hyun-Seo Kang, Christian Wiebeler, Yuka Machida, Dina S Schnapka, Denitsa Yaneva, Christian Renz, Maximilian J. Götz, Pedro Weickert, Abigail C Major, Aldwin Suryo Rahmanto, Sophie M. Gutenthaler, Lena Josefine Daumann, Petra Beli, Helle D. Ulrich, , Julian Stingele
This study shows that ubiquitin activates SPRTN protease to degrade DNA-protein crosslinks, maintaining genome stability and preventing disease.
Nature Communications · Jul 21, 2025Peer-reviewedBiochemistry