Author

Denitsa Yaneva

Ludwig-Maximilians-Universität München

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Julian StingeleiD· 2 shared Abigail C Major· 1 shared Alan E. TomkinsoniD· 1 shared Aldwin Suryo RahmantoiD· 1 shared Brian J. LeeiD· 1 shared Christian RenziD· 1 shared Christian WiebeleriD· 1 shared Demis MenolfiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Julian StingeleORCID

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2 papers

Recent·Most cited

Catalytically inactive PARP1 protein drives PARP inhibitor induced hematological toxicity

Xiaohui Lin, Zhengping Shao, Denitsa Yaneva, Wenxia Jiang, Demis Menolfi, Seema Khattri Bhandari, Brian J. Lee, Mirjam Schmucker, Faye Yaneva, Alan E. Tomkinson, Julian Stingele, Shan Zha

This study shows that catalytically inactive PARP1, not PARP2, is responsible for PARP inhibitor-induced hematological toxicity in mice.

bioRxiv · Sep 25, 2026 · PreprintCancer Biology

Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability

Sophie Dürauer, Hyun-Seo Kang, Christian Wiebeler, Yuka Machida, Dina S Schnapka, Denitsa Yaneva, Christian Renz, Maximilian J. Götz, Pedro Weickert, Abigail C Major, Aldwin Suryo Rahmanto, Sophie M. Gutenthaler, Lena Josefine Daumann, Petra Beli, Helle D. Ulrich, , Julian Stingele

This study shows that ubiquitin activates SPRTN protease to degrade DNA-protein crosslinks, maintaining genome stability and preventing disease.

Nature Communications · Jul 21, 2025Peer-reviewedBiochemistry