Antiretroviral treatment reveals a novel role for lysosomes in oligodendrocyte maturation
Lindsay K. Festa, Abigail E. Clyde, Caela C. Long, Lindsay M. Roth, Judith B. Grinspan, Kelly L. Jordan‐Sciutto
This study shows that bictegravir inhibits oligodendrocyte maturation by causing lysosomal de-acidification, which can be reversed by activating TRPML1.
Journal of Neurochemistry · Jan 31, 2023Peer-reviewedNeuroscience