Judith B. Grinspan

This study shows that deleting TUBB4A in human iPSCs reduces cell-autonomous deficits in oligodendrocytes and neurons associated with H-ABC, suggesting it could be a therapeutic strategy for TUBB4A-related leukodystrophy.

This study shows TRPML1 regulates oligodendrocyte morphology and myelination through actin dynamics and calcium signaling during differentiation.

This study shows that suppressing Tubb4a with an ASO improves symptoms and extends lifespan in a mouse model of H-ABC leukodystrophy.

The paper shows that enhancing oligodendrocyte function in a mouse model of Alzheimer's Disease reduces neuronal damage and slows disease progression.

This study shows that bictegravir inhibits oligodendrocyte maturation by causing lysosomal de-acidification, which can be reversed by activating TRPML1.

This study shows TCF7l2 promotes oligodendrocyte differentiation by repressing autocrine BMP4 signaling, which is dysregulated in multiple sclerosis.