Author

Lindsay M. Roth

AbbVie (United States)ORCID 0000-0001-6452-3386Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Abigail E. Clyde· 1 shared Caela C. LongiD· 1 shared Jan StöhriD· 1 shared Jason SchapanskyiD· 1 shared Judith B. GrinspaniD· 1 shared Kelly L. Jordan‐SciuttoiD· 1 shared Lindsay K. FestaiD· 1 shared Olga Morozova· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 13 mutual co-author links

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1 shared paperNeuroscience

Abigail E. Clyde

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2 papers

Recent·Most cited

NeuroscienceNeurobiology of DiseasePeer-reviewedJan 18, 2026

Astrocytic lysosome deficits reduce alpha-synuclein degradation and induce spread of pathology

Lindsay M. Roth, Olga Morozova, Jan Stöhr, Jason Schapansky

This study shows that astrocytic lysosome deficits impair alpha-synuclein degradation and promote its pathological spread in Parkinson's Disease.

5 citationstop 1%

humanproteomics

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NeuroscienceJournal of NeurochemistryPeer-reviewedJan 31, 2023

Antiretroviral treatment reveals a novel role for lysosomes in oligodendrocyte maturation

Lindsay K. Festa, Abigail E. Clyde, Caela C. Long…·Kelly L. Jordan‐Sciutto

This study shows that bictegravir inhibits oligodendrocyte maturation by causing lysosomal de-acidification, which can be reversed by activating TRPML1.

10 citations

experimental assay

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