Activation of the Spx redox sensor counters cysteine-driven Fe(II) depletion under disulfide stress
Abigail G. Hall, Abdulelah A. Alqarzaee, Aliyah J. Collins, Sasmita Panda, Svetlana Romanova, Sujata S. Chaudhari, Andrew J. Monteith, Dorte Frees, Vinai Chittezham Thomas
This study shows that the Spx redox switch in S. aureus is critical for managing cysteine levels during disulfide stress, preventing Fe(II) depletion and growth inhibition.
bioRxiv · Dec 3, 2025 · PreprintMicrobiology