Abdulelah A. Alqarzaee

This study shows that the Spx redox switch in S. aureus is critical for managing cysteine levels during disulfide stress, preventing Fe(II) depletion and growth inhibition.

This study identifies Spx as a stress regulator that enhances β-lactam resistance and reduces susceptibility to last-line antibiotics in MRSA through a redox-independent mechanism.

This study integrates computational modeling and experimental validation to refine a genome-scale metabolic model of S. aureus, improving its accuracy in predicting gene essentiality and metabolic capabilities.