Dorte Frees

This study shows that the Spx redox switch in S. aureus is critical for managing cysteine levels during disulfide stress, preventing Fe(II) depletion and growth inhibition.

This study uses proteomics and independent component analysis to show ClpX regulates S. aureus responses to iron and oxygen limitation and affects bacterial fitness and virulence.

This study identifies CxaR as an adaptor protein that facilitates ClpXP-mediated degradation of Sle1, regulating cell splitting in Staphylococcus aureus.

This study identifies a temperature-sensitive regulatory mechanism in Staphylococcus aureus involving an RNA and ClpXP protease that controls cell division hydrolases.

This study identifies Spx as a stress regulator that enhances β-lactam resistance and reduces susceptibility to last-line antibiotics in MRSA through a redox-independent mechanism.

The paper shows that ClpX chaperone and a hypermorphic FtsA variant compensate for each other in Staphylococcus aureus cell division by modulating FtsA interactions and septum synthesis.