Restoration of Kv7 channel mediated inhibition reduces cued-reinstatement of cocaine seeking
Jeffrey Parrilla-Carrero, William C. Buchta, Priyodarshan Goswamee, Oliver Paul Culver, Greer McKendrick, Benjamin A. Harlan, Aubin Moutal, Rachel D. Penrod, Abigail Lauer, Viswanathan Ramakrishnan, Rajesh Khanna, Peter W. Kalivas, Arthur C. Riegel
This study identifies a subpopulation of prelimbic cortex neurons that become hyperexcitable after chronic cocaine exposure, and shows that restoring Kv7 channel function reduces cue-induced cocaine seeking.
Journal of Neuroscience · Apr 10, 2018Peer-reviewedNeuroscience