Robust antibiotic sensitization of pathogenic Pseudomonas aeruginosa via negative hysteresis in the cell envelope
Florian Buchholz, Lina M. Upterworth, Leif Tüeffers, Espen Elias Groth, Kira Haas, Daniel Schütz, Abigail Savietto, Aditi Batra, Surajit Pal, Samarpita Banerjee, Badri N. Dubey, Sören Franzenburg, Barbara Kalsdorf, Klaus Friedrich Rabe, Dennis Nurjadi, , Hinrich Schulenburg Y
The paper identifies negative hysteresis as a robust phenomenon in Pseudomonas aeruginosa that enhances antibiotic efficacy through increased aminoglycoside uptake after beta-lactam treatment.
Nature Communications · Mar 26, 2026Peer-reviewedEvolutionary Biology