Author

Florian Buchholz

Christian-Albrechts-Universität zu KielORCID 0000-0003-3882-9132Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Aditi BatraiD· 3 shared Hinrich Schulenburg YiD· 3 shared Leif TüeffersiD· 3 shared Jan RuppiD· 2 shared João BotelhoiD· 2 shared Kira Haas· 2 shared Abigail Savietto· 1 shared Antje MunderiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

Aditi BatraORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Evolutionary BiologyNature CommunicationsPeer-reviewedMar 26, 2026

Robust antibiotic sensitization of pathogenic Pseudomonas aeruginosa via negative hysteresis in the cell envelope

Florian Buchholz, Lina M. Upterworth, Leif Tüeffers…·Hinrich Schulenburg Y

The paper identifies negative hysteresis as a robust phenomenon in Pseudomonas aeruginosa that enhances antibiotic efficacy through increased aminoglycoside uptake after beta-lactam treatment.

2 citationstop 3%

bacteria (other)experimental assay

𝕏 PostBluesky

Evolutionary BiologybioRxivPreprintApr 1, 2025

Resistance variation and bacterial interactions shape the adaptation of a genetically diverse bacterial population to antimicrobial treatment

Aditi Batra, Leif Tüeffers, Kira Haas…·Hinrich Schulenburg Y

This study shows that resistance variation and bacterial interactions influence the adaptation of a genetically diverse Pseudomonas aeruginosa population to antibiotic treatment.

DOI 10.1101/2025.04.01.646401

humanexperimental assay

𝕏 PostBluesky

MicrobiologyMicrobiology SpectrumPeer-reviewedJun 11, 2024

Variation in the response to antibiotics and life-history across the major Pseudomonas aeruginosa clone type (mPact) panel

Leif Tüeffers, Aditi Batra, Johannes Zimmermann…·Hinrich Schulenburg

The paper evaluates antibiotic resistance and life-history traits across 20 Pseudomonas aeruginosa strains to identify adaptive strategies and inform new treatment approaches.

4 citations

humanwhole-genome sequencing

𝕏 PostBluesky