Dan I. Andersson

SPARK: Systematic Profiling of Antibiotic-Phage Response Kinetics

SPARK quantifies phage-antibiotic interactions using growth curves and shows synergy, antagonism, and dynamic changes across bacterial isolates and time.

Unstable Heteroresistance as a Stepping Stone to Stable Resistance via Compensatory Mutations

This study shows that antibiotic heteroresistance can transition to stable resistance via compensatory mutations, leaving no genetic trace in surviving isolates.

Distinct plasmid- and host-encoded mechanisms drive small plasmid copy number-mediated heteroresistance in Escherichia coli

The paper shows small plasmids can cause antibiotic heteroresistance through copy number increases via plasmid mutations or chromosomal recD mutations in Escherichia coli.

Novel phage-plasmid mediated mechanism of antibiotic heteroresistance in Escherichia coli

This study identifies a novel mechanism of antibiotic heteroresistance in E. coli mediated by phage-plasmid copy number increase and horizontal transfer.

Heteroresistance in Enterococcus faecalis is prevalent for key antibiotics and mainly caused by mutations

This study identifies heteroresistance in Enterococcus faecalis against three antibiotics, showing that it is mainly caused by chromosomal mutations and mobile genetic elements.

Robust antibiotic sensitization of pathogenic Pseudomonas aeruginosa via negative hysteresis in the cell envelope

The paper identifies negative hysteresis as a robust phenomenon in Pseudomonas aeruginosa that enhances antibiotic efficacy through increased aminoglycoside uptake after beta-lactam treatment.

A Novel Method for Testing Antifungal Interactions: Assessing Synergy and Antagonism in Candida albicans Clinical Isolates.

This paper introduces a novel in vitro method to assess antifungal synergy and antagonism in C. albicans isolates, showing isolate-specific interaction patterns across three antifungals.

Host-specific adaptation of Legionella pneumophila to single and multiple hosts

This study identifies host-specific mutations in Legionella pneumophila through experimental evolution in two hosts, revealing adaptations in ribosomal proteins and LPS synthesis.

Sublethal Interaction Factor (SIF), a growth-based method to analyse antibiotic combinations at sub-inhibitory concentrations.

The paper introduces the Sublethal Interaction Factor (SIF) assay to analyze antibiotic combinations at sublethal concentrations, showing high sensitivity and specificity compared to existing methods.

Fast Antibiotic Susceptibility Testing based on single cell growth rate measurements

The paper presents a fast antibiotic susceptibility testing method that determines bacterial growth rate responses to antibiotics in under 25 minutes using microfluidic imaging.