Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1 independent transcriptional response.
Joseph C.P. Kruempel, Hillary A. Miller, Megan L. Schaller, Abrielle Fretz, Marshall B. Howington, Marjana Rahman Sarker, Shijiao Huang, Scott F. Leiser
This study shows that mutations in egl-9 and rhy-1 suppress the long-lived phenotype of vhl-1 mutants in C. elegans, indicating a VHL-1-independent role for EGL-9 and RHY-1 in longevity regulation.
GeroScience · May 12, 2020Peer-reviewedGenetics