Marshall B. Howington

fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans

This study shows that fmo-4 in C. elegans extends lifespan and stress resistance by regulating calcium homeostasis through interactions with known longevity pathways.

FMO rewires metabolism to promote longevity throughtryptophan and one carbon metabolism

This study identifies FMO-2's role in promoting longevity in C. elegans by rewiring one carbon metabolism and tryptophan metabolism, linking a single enzyme to metabolic pathways involved in lifespan extension.

Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1 independent transcriptional response.

This study shows that mutations in egl-9 and rhy-1 suppress the long-lived phenotype of vhl-1 mutants in C. elegans, indicating a VHL-1-independent role for EGL-9 and RHY-1 in longevity regulation.