A comprehensive portrait of cilia and ciliopathies from a CRISPR-based screen for Hedgehog signaling
David K. Breslow, Sascha Hoogendoorn, Adam R. Kopp, David W. Morgens, Brandon K. Vu, Margaret C. Kennedy, Kyuho Han, Amy Li, Gaelen T. Hess, Michael Cory Bassik, James Chen, Maxence V. Nachury
This study uses a CRISPR-based screen to identify genes critical for Hedgehog signaling and ciliary function, revealing novel components of ciliary structures and linking congenital heart defects to ciliopathies.
Nature Genetics · Feb 7, 2018Peer-reviewedGenetics