Stress granule component TIA-1 is a specific negative regulator of the non-canonical NLRP3 inflammasome.
Prem Prasad Lamichhane, Aditi Aditi, Blake H. Neil, Paul B. Kilgore, Alfredo G. Torres, Ashok K. Chopra, Parimal Samir
This study identifies TIA-1 as a negative regulator of the non-canonical NLRP3 inflammasome, showing its role in suppressing LPS-induced inflammation and endotoxic shock.
bioRxiv · Jul 12, 2025 · PreprintImmunology