Jason M. Miska

This study shows that preoperative temozolomide exposure in recurrent glioblastoma leads to inflammatory-repair remodeling and a ROCK-linked therapeutic vulnerability, which can be targeted by fasudil.

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

The paper develops RNA nanotherapeutics targeting TAMC cholesterol metabolism to enhance anti-tumor immunity in glioblastoma.

This study shows that microglial fructose metabolism via GLUT5 is critical for glioblastoma growth, as GLUT5-KO mice live longer with reduced tumor progression.

This study evaluates a bispecific T cell-engaging antibody in immunocompetent GBM models, showing improved survival, TME remodeling, and immune memory induction.