Hinda Najem

The paper develops RNA nanotherapeutics targeting TAMC cholesterol metabolism to enhance anti-tumor immunity in glioblastoma.

This study identifies IL-6 as a driver of immunosuppression in glioblastoma, showing that its inhibition enhances response to immune checkpoint therapy and radiotherapy in preclinical models.

This study shows that microglial fructose metabolism via GLUT5 is critical for glioblastoma growth, as GLUT5-KO mice live longer with reduced tumor progression.

This study evaluates a bispecific T cell-engaging antibody in immunocompetent GBM models, showing improved survival, TME remodeling, and immune memory induction.

The paper develops and validates a CNS-specific library and analysis platform using the COMET(TM) system for high-dimensional proteomic multiplex imaging of the central nervous system.