EP300 (p300) mediated histone butyrylation is critical for adipogenesis
Aditya Bhattacharya, Sourav Chatterjee, Utsa Bhaduri, Akash Kumar Singh, Madavan Vasudevan, Koneni V. Sashidhara, Rajdeep Guha, Aamir Nazir, Srikanta Kumar Rath, Nagashayana Natesh, Tapas Kumar Kundu
This study shows that p300-mediated histone butyrylation is essential for adipogenesis and obesity, with a specific inhibitor reducing adipocyte growth and weight gain in mouse models.
Journal of Medicinal Chemistry · Sep 8, 2022Peer-reviewedMolecular Biology