Author

Akash Kumar Singh

Jawaharlal Nehru Centre for Advanced Scientific ResearchORCID 0000-0002-7460-2886Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Tapas Kumar KunduiD· 4 shared Aamir NaziriD· 2 shared Ila Joshi· 2 shared Madavan VasudevaniD· 2 shared Rajdeep GuhaiD· 2 shared Aditya Bhattacharya· 1 shared Alexandros Sanchez-VassopoulosiD· 1 shared Amrish Rai· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersNeuroscience

Tapas Kumar KunduORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintJan 3, 2024

Epigenetic Modulation to perturb the SYNGAP1 Intellectual Disability (ID) that ameliorates synaptic and behavioural deficits

Akash Kumar Singh, Ila Joshi, Neeharika M. N. Reddy…·Tapas Kumar Kundu

This study shows that modulating histone acetylation with a small molecule activator improves synaptic and behavioural deficits in a SYNGAP1 mutation model.

1 citation

mousebulk RNA-seq

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NeurosciencebioRxivPreprintOct 4, 2023

Oral Administration of a specific p300/CBP Lysine Acetyltransferase Activator Induces Synaptic Plasticity and Repairing Spinal Cord Injury

Akash Kumar Singh, Amrish Rai, Ila Joshi…·Tapas Kumar Kundu

This study shows oral administration of CSP-TTK21 achieves synaptic plasticity and spinal cord injury repair effects similar to intraperitoneal delivery in mice and rats.

2 citations

mouserat

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Molecular BiologyJournal of Medicinal ChemistryPeer-reviewedSep 8, 2022

EP300 (p300) mediated histone butyrylation is critical for adipogenesis

Aditya Bhattacharya, Sourav Chatterjee, Utsa Bhaduri…·Tapas Kumar Kundu

This study shows that p300-mediated histone butyrylation is essential for adipogenesis and obesity, with a specific inhibitor reducing adipocyte growth and weight gain in mouse models.

22 citations

mouseChIP-seq

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NeurosciencebioRxivPreprintJun 7, 2021

Combinatorial small molecule-mediated activation of CBP/p300 with environmental enrichment in chronic severe experimental spinal cord injury to enable axon regeneration and sprouting for functional recovery

Franziska Müller, Francesco De Virgiliis, Guiping Kong…·Simone Di Giovanni

1 citation

mouseexperimental assay

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