Author

Rajdeep Guha

Central Drug Research InstituteORCID 0000-0002-4451-6995Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Aamir NaziriD· 2 shared Akash Kumar SinghiD· 2 shared Tapas Kumar KunduiD· 2 shared Aditya Bhattacharya· 1 shared Adrija Rakshit· 1 shared Amit LahiriiD· 1 shared Amita AggarwaliD· 1 shared Amrish Rai· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Aamir NazirORCID

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3 papers

Recent·Most cited

Mitochondrial calcium uniporter regulates human fibroblast-like synoviocytes invasion via altering mitochondrial dynamics and dictates rheumatoid arthritis pathogenesis

Lakra Promila, Kabita Sarkar, Shivika Guleria, Adrija Rakshit, Manisha Rathore, Nishakumari C Singh, Shaziya Khan, Manendra Singh Tomar, Veena Ammanathan, Manoj Kumar Barthwal, Jagavelu Kumaravelu, Ashutosh Shrivastava, Kalyan Mitra, Rajdeep Guha, Amita Aggarwal, Amit Lahiri

This study shows that inhibiting the mitochondrial calcium uniporter reduces fibroblast-like synoviocytes migration and mitochondrial dysfunction in rheumatoid arthritis.

Free Radical Biology and Medicine · Apr 6, 2025Peer-reviewedImmunology

Oral Administration of a specific p300/CBP Lysine Acetyltransferase Activator Induces Synaptic Plasticity and Repairing Spinal Cord Injury

Akash Kumar Singh, Amrish Rai, Ila Joshi, Damodara N. Reddy, Rajdeep Guha, Shubha Shukla, Aamir Nazir, James Premdoss Clement, Tapas Kumar Kundu

This study shows oral administration of CSP-TTK21 achieves synaptic plasticity and spinal cord injury repair effects similar to intraperitoneal delivery in mice and rats.

bioRxiv · Oct 4, 2023 · PreprintNeuroscience

EP300 (p300) mediated histone butyrylation is critical for adipogenesis

Aditya Bhattacharya, Sourav Chatterjee, Utsa Bhaduri, Akash Kumar Singh, Madavan Vasudevan, Koneni V. Sashidhara, Rajdeep Guha, Aamir Nazir, Srikanta Kumar Rath, Nagashayana Natesh, Tapas Kumar Kundu

This study shows that p300-mediated histone butyrylation is essential for adipogenesis and obesity, with a specific inhibitor reducing adipocyte growth and weight gain in mouse models.

Journal of Medicinal Chemistry · Sep 8, 2022Peer-reviewedMolecular Biology