This study identifies T13F2.2 as a critical gene in C. elegans that affects chromatin structure, autophagy, and lifespan through RNAi depletion and transcriptomic analysis.

bioRxiv · Sep 22, 2025 · PreprintGenetics

Oral Administration of a specific p300/CBP Lysine Acetyltransferase Activator Induces Synaptic Plasticity and Repairing Spinal Cord Injury

Akash Kumar Singh, Amrish Rai, Ila Joshi, Damodara N. Reddy, Rajdeep Guha, Shubha Shukla, Aamir Nazir, James Premdoss Clement, Tapas Kumar Kundu

This study shows oral administration of CSP-TTK21 achieves synaptic plasticity and spinal cord injury repair effects similar to intraperitoneal delivery in mice and rats.

bioRxiv · Oct 4, 2023 · PreprintNeuroscience

EP300 (p300) mediated histone butyrylation is critical for adipogenesis

Aditya Bhattacharya, Sourav Chatterjee, Utsa Bhaduri, Akash Kumar Singh, Madavan Vasudevan, Koneni V. Sashidhara, Rajdeep Guha, Aamir Nazir, Srikanta Kumar Rath, Nagashayana Natesh, Tapas Kumar Kundu

This study shows that p300-mediated histone butyrylation is essential for adipogenesis and obesity, with a specific inhibitor reducing adipocyte growth and weight gain in mouse models.

Journal of Medicinal Chemistry · Sep 8, 2022Peer-reviewedMolecular Biology

Penetratin inhibits α-synuclein fibrillation and improves locomotor functions in mice model of Parkinsons disease

Arpit Gupta, Priyanka Singh, Arpit Mehrotra, Ankur Gautam, Kottapalli Srividya, Rajlaxmi Panigrahi, Shubham Vashishtha, Jasdeep Singh, Gagandeep Jaiswal, Krishna Upadhayay, Signe Andrea Frank, Janni Nielsen, Samir Kumar Nath, Neeraj Khatri, Daniel E. Otzen, , Deepak Sharma

This study identifies penetratin as an inhibitor of α-synuclein aggregation and shows it improves locomotor function in Parkinson's disease mouse models.

bioRxiv · Jun 24, 2022 · PreprintNeuroscience