Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling
Adolf Koudelka, Gregory J. Buchan, Veronika Cechova, James P. O’Brien, Heng Liu, Steven R. Woodcock, Steven J. Mullett, Cheng Zhang, Bruce A. Freeman, Stacy L. Gelhaus
This paper shows that LXA4 and its 15-oxo metabolite do not activate FPR2 receptor but instead modulate redox-sensitive pathways through electrophilic interactions.
bioRxiv · Feb 6, 2024 · PreprintBiochemistry