Stacy L. Gelhaus

Acetylated PLIN2 coordinates the innate immune system and oxylipin synthesis on lipid droplets to propagate inflammation

This study identifies acetylated PLIN2 as a critical mediator of inflammation by facilitating oxylipin synthesis on lipid droplets through interactions with inflammatory proteins.

Proteomic analysis in Alzheimer's disease with psychosis reveals a shared AD proteomic landscape and a separate molecular signature of postsynaptic density disruption

This study identifies a shared proteomic profile in Alzheimer's disease with and without psychosis and a separate molecular signature linked to postsynaptic density disruption.

Intracellular glutamine fluctuates with nitrogen availability and regulates Mycobacterium smegmatis biofilm formation

This paper shows that intracellular glutamine levels, influenced by nitrogen availability, regulate biofilm formation in Mycobacterium smegmatis by affecting aggregation.

CYB5R4 sustains endothelial proliferation and ischemia-induced angiogenesis by maintaining RRM2-dependent nucleotide balance

This study identifies CYB5R4 as a regulator of endothelial proliferation and ischemia-induced angiogenesis through RRM2-dependent nucleotide balance.

Adropin protects against cardiac remodeling and metabolic dysfunction in a mouse model of HFpEF

This study shows Adropin treatment reverses cardiac dysfunction and metabolic defects in a mouse model of HFpEF by reducing O-GlcNAcylation of LCAD and improving fatty acid oxidation.

Myoglobin Inhibits Breast Cancer Cell Fatty Acid Oxidation and Migration via Heme-Dependent Oxidant Production and Not Fatty Acid Binding

The microbiota extends the reproductive lifespan by safeguarding the ovarian reserve

This study shows that the microbiota influences reproductive lifespan by maintaining the ovarian reserve through short chain fatty acids and gene regulatory networks.

TCA Cycle Dysfunction and Amino Acid Catabolism Drive Hepatic Steatosis in Mice with HFpEF

This study shows that TCA cycle dysfunction and amino acid catabolism in mice with HFpEF drive hepatic steatosis similar to human NAFLD.

Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling

This paper shows that LXA4 and its 15-oxo metabolite do not activate FPR2 receptor but instead modulate redox-sensitive pathways through electrophilic interactions.

Circadian rhythms in the gut microbiota shape sex differences in host gene expression and metabolism

This study shows that microbial circadian rhythms influence sex differences in host gene expression and metabolism, with diet affecting these sex-specific patterns.