ZFAND6 is a subunit of a TRAF2-cIAP E3 ubiquitin ligase complex essential for mitophagy
Kashif Shaikh, Melissa Bowman, Sarah M. McCormick, Linlin Gao, Jiawen Zhang, John Tawil, Arun Kapoor, Ravit Arav‐Boger, Young Bong Choi, Andrew S Pekosz, Sabra L. Klein, Matthew Lanza, Julie C. Fanburg–Smith, Adolfo García-Sastre, Christopher C. Norbury, , Edward William Harhaj
This study identifies ZFAND6 as a component of a TRAF2-cIAP E3 ubiquitin ligase complex that regulates mitophagy, maintaining mitochondrial homeostasis and influencing immune responses to viral infection.
iScience · Dec 6, 2024Peer-reviewedImmunology