Author

Edward William Harhaj

Pennsylvania State UniversityORCID 0000-0003-1197-6765Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Organism:mouse· 2 Organism:human· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Zissis C. ChroneosiD· 2 shared Adolfo García-Sastre· 1 shared Andrew S PekosziD· 1 shared Arun KapooriD· 1 shared Christopher C. NorburyiD· 1 shared Jiawen ZhangiD· 1 shared John Tawil· 1 shared Julie C. Fanburg–SmithiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Zissis C. ChroneosORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintJun 30, 2025

The aryl hydrocarbon receptor interacting protein suppresses RNA virus-induced type I IFN and IL-6 in mouse macrophages

Sarah A. Kazzaz, Todd M. Umstead, Zissis C. Chroneos, Edward William Harhaj

This study shows that AIP suppresses type I IFN and IL-6 production in mouse macrophages during RNA virus infection by regulating IRF7 degradation.

DOI 10.1101/2025.06.30.662398

mouseproteomics

𝕏 PostBluesky

MicrobiologybioRxivPreprintMar 15, 2025

HTLV-1 Tax induces PINK1-Parkin-dependent mitophagy to mitigate activation of the cGAS-STING pathway

Suchitra Mohanty, Sujit Suklabaidya, Nelli Mnatsakanyan…·Edward William Harhaj

This study shows HTLV-1 Tax induces mitophagy via PINK1-Parkin to suppress cGAS-STING activation and type I IFN, aiding viral persistence and cell survival.

1 citation

humanproteomics

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ImmunologyiSciencePeer-reviewedDec 6, 2024

ZFAND6 is a subunit of a TRAF2-cIAP E3 ubiquitin ligase complex essential for mitophagy

Kashif Shaikh, Melissa Bowman, Sarah M. McCormick…·Edward William Harhaj

This study identifies ZFAND6 as a component of a TRAF2-cIAP E3 ubiquitin ligase complex that regulates mitophagy, maintaining mitochondrial homeostasis and influencing immune responses to viral infection.

6 citations

mouseproteomics

𝕏 PostBluesky