High-resolution cryo-electron microscopy of the human CDK-activating kinase for structure-based drug design
Victoria I. Cushing, Adrian F. Koh, Junjie Feng, Kaste Jurgaityte, Ash K. Bahl, Simak Ali, Abhay Kotecha, Basil J. Greber
The paper determines high-resolution structures of CDK-activating kinase using cryo-EM, revealing inhibitor interactions and providing a framework for structure-based drug design.
bioRxiv · Apr 7, 2023 · PreprintMolecular Biology