Author

Victoria I. Cushing

Institute of Cancer ResearchORCID 0000-0002-7976-0859Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Basil J. GreberiD· 4 shared Abhay KotechaiD· 2 shared Adrian F. Koh· 1 shared Alexandru Radu AricescuiD· 1 shared Amy J. S. McGeochiD· 1 shared Ash K. BahliD· 1 shared Benjamin BasantaiD· 1 shared Caroline BenziD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersMolecular Biology

Basil J. GreberORCID

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Author profile →

4 papers

Recent·Most cited

Cryo-EM structures of the CDK11-cyclin L-SAP30BP complex reveal mechanisms of CDK11 regulation

Amy J. S. McGeoch, Victoria I. Cushing, Theodoros I. Roumeliotis, Nora Cronin, Stephen James Hearnshaw, Jyoti Sharma Choudhary, Claudio Alfieri, Basil J. Greber

The paper presents the cryo-EM structure of the CDK11-cyclin L-SAP30BP complex, revealing mechanisms of CDK11 regulation and inhibitor selectivity.

Nature Communications · Apr 25, 2026Peer-reviewedMolecular Biology

High-throughput discovery and deep characterization of cyclin-CDK docking motifs

Mihkel Örd, Matthew J. Winters, Mythili S. Subbanna, Natàlia de Martín Garrido, Victoria I. Cushing, Johanna Kliche, Caroline Benz, Ylva Ivarsson, Basil J. Greber, Peter M. Pryciak, Norman E. Davey

The paper identifies and characterizes cyclin-CDK docking motifs through high-throughput peptide binding assays and structural analysis, revealing a broader repertoire of motif types and binding mechanisms.

Nature Communications · Aug 15, 2025Peer-reviewedMolecular Biology

Sub-3 A resolution protein structure determination by single-particle cryo-EM at 100 keV

Dimple Karia, Fujiet Koh, Wen Yang, Victoria I. Cushing, Benjamin Basanta, Daniel B. Mihaylov, Sagar Khavnekar, Ondřej Vyroubal, Miloš Malínský, Ondřej Sháněl, Vojtěch Doležal, Jürgen M. Plitzko, Lingbo Yu, Gabriel C. Lander, Alexandru Radu Aricescu, , Abhay Kotecha

This paper demonstrates that a 100 keV cryo-TEM with advanced components can achieve sub-3 Å resolution structures of various proteins and viruses.

Structure · Jul 30, 2025Peer-reviewedBiophysics

High-resolution cryo-electron microscopy of the human CDK-activating kinase for structure-based drug design

Victoria I. Cushing, Adrian F. Koh, Junjie Feng, Kaste Jurgaityte, Ash K. Bahl, Simak Ali, Abhay Kotecha, Basil J. Greber

The paper determines high-resolution structures of CDK-activating kinase using cryo-EM, revealing inhibitor interactions and providing a framework for structure-based drug design.

bioRxiv · Apr 7, 2023 · PreprintMolecular Biology