Simak Ali

The paper identifies X15695 as an AHR ligand that promotes ER degradation and inhibits ER+ breast cancer cell proliferation more effectively than fulvestrant.

This study creates a mouse model with human APOBEC3 genes to study their expression and anti-viral functions, showing human-like regulation and functional responses.

This study investigates molecular glues targeting the ER/14-3-3 PPI to overcome endocrine resistance in breast cancer, showing suppression of ER activity and cell proliferation.

This study investigates the antitumour activity of CT7001, a CDK7 inhibitor, in castration-resistant prostate cancer models, showing it inhibits proliferation and enhances enzalutamide efficacy.

The paper determines high-resolution structures of CDK-activating kinase using cryo-EM, revealing inhibitor interactions and providing a framework for structure-based drug design.

This study compares AS-Mini-LAMP and PSR for amplifying short DNA templates, finding AS-Mini-LAMP more effective for mutant allele detection.