Ectopic activation of the polar body extrusion pathway triggers cell fragmentation in preimplantation embryos
Diane Pelzer, Ludmilla de Plater, Peta Bradbury, Adrien Eichmuller, Anne Bourdais, Guillaume Halet, Jean‐Léon Maître
This study identifies that ectopic activation of the polar body extrusion pathway during mitosis in preimplantation embryos triggers cell fragmentation through actomyosin contractility.
bioRxiv · Dec 22, 2022 · PreprintDevelopmental Biology