Chemoproteomics identifies a pyrimidopyrimidine analogue as a tubulin-tyrosine ligase binder
Rubaba R Abanti, Eleftheria A. Georgiou, Dmytro Makarov, Severin Lechner, Afroditi Tsigara, Bernhard Küster, Guillaume Médard, Pavel Kielkowski, Leentje Persoons, Steven De Jonghe, Ioannis K. Kostakis
The paper identifies CEM198 as a TTL binder through chemoproteomics, showing it disrupts microtubule dynamics via dual mechanisms in different cell lines.
bioRxiv · Aug 7, 2026 · PreprintBiochemistry