Guillaume Médard

Chemoproteomics identifies a pyrimidopyrimidine analogue as a tubulin-tyrosine ligase binder

The paper identifies CEM198 as a TTL binder through chemoproteomics, showing it disrupts microtubule dynamics via dual mechanisms in different cell lines.

High-throughput chemical proteomics workflow for profiling protein citrullination dynamics

The paper develops a chemical proteomics workflow to profile protein citrullination dynamics, achieving high sensitivity and throughput in detecting citrullinated peptides across biological systems.

Learning the Unseen: Data-Augmented Deep Learning for PTM Discovery with Prosit-PTM

This paper introduces Prosit-PTM, a deep learning model for PTM discovery that improves zero-shot prediction using a synthetic dataset and chemically-informed encoding.