Author

Leentje Persoons

KU LeuvenORCID 0000-0002-7898-0868Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 1

Frequent Co-Authors

Abhimanyu Kumar SinghiD· 1 shared Afroditi Tsigara· 1 shared Annelies StevaertiD· 1 shared Arnout R. D. VoetiD· 1 shared Benjamin Van LoyiD· 1 shared Bernhard KüsteriD· 1 shared Bert VanmecheleniD· 1 shared Besir KrasniqiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMicrobiology

Abhimanyu Kumar SinghORCID

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2 papers

Recent·Most cited

Chemoproteomics identifies a pyrimidopyrimidine analogue as a tubulin-tyrosine ligase binder

Rubaba R Abanti, Eleftheria A. Georgiou, Dmytro Makarov, Severin Lechner, Afroditi Tsigara, Bernhard Küster, Guillaume Médard, Pavel Kielkowski, Leentje Persoons, Steven De Jonghe, Ioannis K. Kostakis

The paper identifies CEM198 as a TTL binder through chemoproteomics, showing it disrupts microtubule dynamics via dual mechanisms in different cell lines.

bioRxiv · Aug 7, 2026 · PreprintBiochemistry

A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses

Benjamin Van Loy, Eugènia Pujol, Kenichi Kamata, Xiao Yin Lee, Nikolai Bakirtzoglou, Ria Van Berwaer, Julie Vandeput, Cato Mestdagh, Leentje Persoons, Brent De Wijngaert, Quinten Goovaerts, Sam Noppen, Maarten Jacquemyn, Kourosh Ahmadzadeh, Eline Bernaerts, , Annelies Stevaert

This paper identifies EPB-113, a guanidine-based inhibitor of coronavirus nsp15 endoribonuclease, which suppresses viral replication and selects for interferon-susceptible mutants.

PLoS Pathogens · Feb 11, 2025Peer-reviewedMicrobiology