Amyloid beta Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer's Disease
Priya Prakash, Palak Manchanda, Evangelia Paouri, Kanchan Bisht, Kaushik P. Sharma, Jitika Rajpoot, Victoria Wendt, Ahad Hossain, Prageeth R. Wijewardhane, Caitlin E. Randolph, Yihao Chen, Sarah Stanko, Nadia Gasmi, Anxhela Gjojdeshi, Sophie Card, , Gaurav Chopra
This study identifies lipid droplet formation in microglia as a mechanism linking amyloid-beta exposure to impaired phagocytosis in Alzheimer's disease, with DGAT2 as a therapeutic target.
Alzheimer s & Dementia · Dec 1, 2023Peer-reviewedNeuroscience