Chi Zhang

This study identifies PI(3,4,5)P3 as a regulator of yeast vacuole fusion, showing it controls vertex microdomain assembly and retains the SNARE Vam7 on membranes.

This paper introduces epi-CARS microscopy to image cell adhesion dynamics with high resolution, revealing adhesion site splitting and heterogeneous adhesion patterns during mitosis and postmitotic spreading.

This paper introduces a software-assisted real-time optical manipulation platform for precise control of intracellular processes and cell functions.

This study uses stimulated Raman scattering microscopy to rapidly and label-free monitor apoptotic and necrotic transitions in CHO cells, identifying distinct subpopulations and responses to stressors.

This paper introduces fs-RPOC, a method for real-time, site-specific perturbation of subcellular compartments using femtosecond laser pulses, demonstrating its ability to modulate mitochondria and observe molecular responses.

This study evaluates SQ109's antifungal activity against sixteen fungal pathogens and identifies its mechanisms involving mitochondrial targeting and isoprenoid biosynthesis pathway inhibition.

This study identifies lipid droplet formation in microglia as a mechanism linking amyloid-beta exposure to impaired phagocytosis in Alzheimer's disease, with DGAT2 as a therapeutic target.